2026-04-17T13:57:16Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/102222024-12-13T10:29:25Zcom_2072_378070com_2072_378040col_2072_378092

Assessment of dyspneic sensation in patients with type 2 diabetes Mizab Mellah, Chadia Sánchez, Enric Gutiérrez Carrasquilla, Liliana Balsells, Núria Arqué, Anaïs Ruano Esteban, Raquel Hernández Pascual, Cristina Simó Canonge, Rafael Diabetis no-insulinodependent - Complicacions Dispnea DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 Other subheadings::Other subheadings::Other subheadings::/complications ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Respiratory::Dyspnea ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::signos y síntomas respiratorios::disnea Diabetes complications; Questionnaires; Respiratory symptoms Complicaciones de la diabetes; Questionarios; Síntomas respiratorios Complicacions de la diabetis; Qüestionaris; Símptomes respiratoris Introduction: Individuals with type 2 diabetes (T2D) should be considered a susceptible group for pulmonary dysfunction. So, we aimed to evaluate the sensation of breathlessness in this population by administering two well-validated questionnaires. Methods: This is a crosssectional study with 592 people without known respiratory disease (353 with T2D) who answered the modified Medical Research Council (mMRC) questionnaire. In addition, 47% also responded to the St George Respiratory Questionnaire, a specific instrument designed to be applied to patients with obstructive airway disease. Results: Patients with T2D showed a higher mMRC score in comparison to the control group [1.0 (0.0 – 4.0) vs. 0.0 (0.0 – 4.0), p<0.001]. A higher prevalence of subjects with mMRC ≥2 was observed in T2D that in the control group (20.2% vs. 11.6%, p=0.004). Participants with T2D and mMRC ≥2 showed a higher HbA1c (8.2 ± 1.6% vs. 7.8 ± 1.6%, p=0.048), longer T2D evolution and higher prevalence of nephropathy. In the multivariate analysis, the presence of T2D [OR=1.95 (1.19 to 3.22), p=0.008] in all the population, and HbA1c [OR=1.19 (1.01 to 1.41), p=0.034] and the presence of diabetic nephropathy [OR=2.00 (1.14 to 3.52), p=0.015] in patients with T2D, predicted a mMRC ≥2. Finally, no differences were observed regarding the SGRQ score among groups. Conclusions: Patients with T2D showed a greater sensation of dyspnea than subjects with normal carbohydrate metabolism. Risk factors included poor metabolic control and the presence of renal disease. This research was supported by grants from Instituto de Salud Carlos III (PI15/00260), Fondos FEDER “Una manera de hacer Europa”), and Sociedad Española de Endocrinología y Nutrición. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) is an initiative of the Instituto Carlos III. 2023-11-06T10:28:43Z 2023-11-06T10:28:43Z 2023-11-06T10:28:43Z 2023-09-04T12:26:34Z 2023-09-04T12:26:34Z 2023-08-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/10222 Frontiers in Endocrinology;14 https://doi.org/10.3389/fendo.2023.1208020 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Frontiers Media Scientia