2026-04-17T19:07:34Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/101972025-10-24T10:30:29Zcom_2072_378070com_2072_378040col_2072_378092

Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain Gonzalez-Juanatey, Carlos Anguita-Sánchez, Manuel barrios, vivencio Garcia-Moll, Xavier Nuñez Gil, Ivan Javier Gomez Doblas, Juan Jose Soriano Colomé, Toni Institut Català de la Salut [González-Juanatey C] Hospital Universitario Lucus Augusti, Lugo, Spain. [Anguita-Sánchez M] Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Cordoba, Spain. [Barrios V] Hospital Universitario Ramón y Cajal, Madrid, Spain. [Núñez-Gil I] Cardiology Department, Hospital Clínico Universitario San Carlos, Madrid, Spain. Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain. [Gómez-Doblas JJ] IBIMA (Instituto de Investigación Biomédica de Málaga), Hospital Universitario Virgen de la Victoria, CIBERCV (Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares), Malaga, Spain. [García-Moll X] Hospital Universitario Santa Creu i Sant Pau, Barcelona. [Soriano-Colomé T] Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV (Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Diabetis no-insulinodependent - Complicacions Sistema cardiovascular - Malalties Persones grans DISEASES::Cardiovascular Diseases NAMED GROUPS::Persons::Age Groups::Adult::Aged DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 Other subheadings::Other subheadings::Other subheadings::/complications ENFERMEDADES::enfermedades cardiovasculares DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adulto::anciano ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo II Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones Coronary artery disease; Type 2 diabetes mellitus Arteriopatía coronaria; Diabetes mellitus tipo 2 Arteriopatia coronària; Diabetis mellitus tipus 2 Patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) without myocardial infarction (MI) or stroke are at high risk for major cardiovascular events (MACEs). We aimed to provide real-world data on age-related clinical characteristics, treatment management, and incidence of major cardiovascular outcomes in T2DM-CAD patients in Spain from 2014 to 2018. We used EHRead® technology, which is based on natural language processing and machine learning, to extract unstructured clinical information from electronic health records (EHRs) from 12 hospitals. Of the 4072 included patients, 30.9% were younger than 65 years (66.3% male), 34.2% were aged 65–75 years (66.4% male), and 34.8% were older than 75 years (54.3% male). These older patients were more likely to have hypertension (OR 2.85), angina (OR 1.64), heart valve disease (OR 2.13), or peripheral vascular disease (OR 2.38) than those aged <65 years (p < 0.001 for all comparisons). In general, they were also more likely to receive pharmacological and interventional treatments. Moreover, these patients had a significantly higher risk of MACEs (HR 1.29; p = 0.003) and ischemic stroke (HR 2.39; p < 0.001). In summary, patients with T2DM-CAD in routine clinical practice tend to be older, have more comorbidities, are more heavily treated, and have a higher risk of developing MACE than is commonly assumed from clinical trial data. This study was funded and sponsored by the Spanish Society of Cardiology. 2023-08-31T11:37:05Z 2023-08-31T11:37:05Z 2023-08-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion González-Juanatey C, Anguita-Sánchez M, Barrios V, Núñez-Gil I, Gómez-Doblas JJ, García-Moll X, et al. Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain. J Clin Med. 2023 Aug 10;12(16):5218. 2171-8695 https://hdl.handle.net/11351/10197 10.3390/jcm12165218 37629262 http://hdl.handle.net/11351/10197 eng Journal of Clinical Medicine;12(16) https://doi.org/10.3390/jcm12165218 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia