2026-04-17T06:26:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/100952025-10-24T10:27:06Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:27:06Z urn:hdl:11351/10095 Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer Benavente, Sergi Cap - Càncer - Immunoteràpia Coll - Càncer - Immunoteràpia DISEASES::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral Tumor microenvironments; Head and neck cancer; Radiotherapy Microambientes tumorales; Cáncer de cabeza y cuello; Radioterapia Microambients tumorals; Càncer de cap i coll; Radioteràpia Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer. 2025-10-24T10:27:06Z 2025-10-24T10:27:06Z 2023-08-17T11:50:51Z 2023-08-17T11:50:51Z 2023-05-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/10095 Cancer Drug Resistance;6 http://dx.doi.org/10.20517/cdr.2022.141 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess OAE Publishing Scientia