2026-04-05T10:38:08Zhttps://recercat.cat/oai/requestoai:recercat.cat:10459.1/734472024-12-05T21:25:31Zcom_2072_3622col_2072_479130
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
de Rojas, Itziar
Hernández, Isabel
Montrreal, Laura
Quintela, Inés
Calero, Miguel
Royo Sánchez-Palencia, José Luis
Huerto Vilas, Raquel
González Pérez, Antonio
Franco Macías, Emilio
Macías, Juan
Menéndez González, Manuel
Frank García, Ana
Diez Fairen, Mónica
Lage, Carmen
García Madrona, Sebastián
Aguilera, Nuria
García González, Pablo
Puerta, Raquel
Sotolongo Grau, Oscar
Alonso Lana, Silvia
Rábano, Alberto
Arias Pastor, Alfonso
Pastor, Ana Belén
Corma Gómez, Anaïs
Martín Montes, Ángel
Martínez Rodríguez, Carmen
Buiza Rueda, Dolores
Rodríguez Rodríguez, Eloy
Álvarez, Ignacio
Rosas Allende, Irene
Pineda, Juan A.
Bernal Sánchez-Arjona, María
Fernández Fuertes, Marta
Mendoza, Silvia
Del Ser, Teodoro
García Ribas, Guillermo
Sánchez Juan, Pascual
Pastor, Pau
Bullido, María J.
Álvarez, Victoria
Real, Luis M.
Mir, Pablo
Piñol Ripoll, Gerard
García Alberca, Jose María
Medina, Miguel
Orellana, Adelina
Butler, Chris R.
Marquié, Marta
Sáez, María Eugenia
Carracedo, Angel
Tárraga, Lluís
Boada, Mercè
Ruiz, Agustín
APOE
COVID-19
GR@ACE/DEGESCO
GWAS
SARS-CoV-2
Dementia
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
2024-12-05T21:25:31Z
2024-12-05T21:25:31Z
2022-03-30T11:07:48Z
2022-03-30T11:07:48Z
2021
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://hdl.handle.net/10459.1/73447
Reproducció del document publicat a: https://doi.org/10.3390/jpm11121318.
Journal of Personalized Medicine, 2021, vol. 11, núm. 12
cc-by (c) Authors, 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
MDPI