2026-04-17T03:25:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/734472024-12-05T21:25:31Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc de Rojas, Itziar author Hernández, Isabel author Montrreal, Laura author Quintela, Inés author Calero, Miguel author Royo Sánchez-Palencia, José Luis author Huerto Vilas, Raquel author González Pérez, Antonio author Franco Macías, Emilio author Macías, Juan author Menéndez González, Manuel author Frank García, Ana author Diez Fairen, Mónica author Lage, Carmen author García Madrona, Sebastián author Aguilera, Nuria author García González, Pablo author Puerta, Raquel author Sotolongo Grau, Oscar author Alonso Lana, Silvia author Rábano, Alberto author Arias Pastor, Alfonso author Pastor, Ana Belén author Corma Gómez, Anaïs author Martín Montes, Ángel author Martínez Rodríguez, Carmen author Buiza Rueda, Dolores author Rodríguez Rodríguez, Eloy author Álvarez, Ignacio author Rosas Allende, Irene author Pineda, Juan A. author Bernal Sánchez-Arjona, María author Fernández Fuertes, Marta author Mendoza, Silvia author Del Ser, Teodoro author García Ribas, Guillermo author Sánchez Juan, Pascual author Pastor, Pau author Bullido, María J. author Álvarez, Victoria author Real, Luis M. author Mir, Pablo author Piñol Ripoll, Gerard author García Alberca, Jose María author Medina, Miguel author Orellana, Adelina author Butler, Chris R. author Marquié, Marta author Sáez, María Eugenia author Carracedo, Angel author Tárraga, Lluís author Boada, Mercè author Ruiz, Agustín author 2022-03-30T11:07:48Z 2022-03-30T11:07:48Z 2021 Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis. http://hdl.handle.net/10459.1/73447 APOE COVID-19 GR@ACE/DEGESCO GWAS SARS-CoV-2 Dementia Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study