2026-04-13T08:15:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/727122024-12-05T22:02:56Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Torres, Antoni author Motos, Anna author Riera, Jordi author Fernández Barat, Laia author Ceccato, Adrián author Pérez Arnal, Raquel author García Gasulla, Darío author Peñuelas, Oscar author Lorente, José Ángel author Rodríguez, Alejandro author de Gonzalo Calvo, David author Almansa, Raquel author Gabarrús, Albert author Menéndez, Rosario author Bermejo Martin, Jesús F. author Ferrer, Ricard author Amaya Villar, Rosario author Añón, José M. author Barberà, Carme author Barberán, José author Blandino Ortiz, Aaron author Bustamante Munguira, Elena author Caballero, Jesús author Carbajales, Cristina author Carbonell, Nieves author Catalán González, Mercedes author Galbán, Cristóbal author Gumucio Sanguino, Víctor D. author de la Torre, Maria del Carmen author Díaz, Emili author Estella, Ángel author Gallego, Elena author García Garmendia, José Luis author Garnacho Montero, José author Gómez, José Manuel author Huerta, Arturo author Jorge García, Ruth Noemí author Loza Vázquez, Ana author Marin Corral, Judith author Martínez de la Gándara, Amalia author Martínez Varela, Ignacio author López Messa, Juan author Albaiceta, Guillermo M. author Novo, Mariana Andrea author Peñasco, Yhivian author Pozo Laderas, Juan Carlos author Ricart, Pilar author Salvador Adell, Inmaculada author Sánchez Miralles, Angel author Sancho Chinesta, Susana author Socias, Lorenzo author Solé Violan, Jordi author Suares Sipmann, Fernando author Tamayo Lomas, Luis author Trenado, José author Barbé Illa, Ferran author 2022-01-12T13:03:24Z 2022-01-12T13:03:24Z 2021 Correcció de l'article publicat a: https://doi.org/10.1186/s13054-021-03849-2 Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation. Financial support was provided by the Instituto de Salud Carlos III de Madrid (COV20/00110, ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa", and by the Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES). DdGC has received fnancial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by European Social Fund (ESF)/”Investing in your future”. http://hdl.handle.net/10459.1/72712 COVID-19 Coronavirus Mechanical ventilation SARS-CoV-2 Ventilatory ratio The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients