2026-04-17T13:02:09Zhttps://recercat.cat/oai/requestoai:recercat.cat:10459.1/725982024-12-05T22:51:54Zcom_2072_3622col_2072_479130
RECERCAT
author
Pujol Carrión, Núria
author
Pavón Vergés, Mónica
author
Arroyo, Javier
author
Torre Ruiz, M. A. de la
2024-12-05T22:51:54Z
2024-12-05T22:51:54Z
2021-12-20T09:54:20Z2021
http://hdl.handle.net/10459.1/72598
Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions. The lack of Slt2 provokes Aft1 dysfunction leading to a shorter chronological life span. The signal of iron scarcity is not transmitted to Slt2 through other signalling pathways such as TOR1, PKA, SNF1 or TOR2/YPK1. The observation that Slt2 physically binds Aft1 rather suggests a direct regulation.
cc-by (c) the autors, 2021 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
Aft1
Chronological life span
Iron homeostasis
MAPK
Slt2
The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion