2026-04-17T15:57:55Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/725982024-12-05T22:51:54Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Pujol Carrión, Núria author Pavón Vergés, Mónica author Arroyo, Javier author Torre Ruiz, M. A. de la author 2021-12-20T09:54:20Z 2021 Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions. The lack of Slt2 provokes Aft1 dysfunction leading to a shorter chronological life span. The signal of iron scarcity is not transmitted to Slt2 through other signalling pathways such as TOR1, PKA, SNF1 or TOR2/YPK1. The observation that Slt2 physically binds Aft1 rather suggests a direct regulation. http://hdl.handle.net/10459.1/72598 Aft1 Chronological life span Iron homeostasis MAPK Slt2 The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1