2026-04-13T04:33:55Zhttps://recercat.cat/oai/request
oai:recercat.cat:10459.1/695712024-12-05T21:56:34Zcom_2072_3622col_2072_479130
RECERCAT author Baratelli, Massimiliano author Morgan, Sophie author Hemmink, Johanneke Dinie author Reid, Elisabeth author Carr, Brigid Veronica author Lefevre, Eric author Montaner Tarbes, Sergio Roberto author Charleston, Bryan author Fraile Sauce, Lorenzo José author Tchilian, Elma author Montoya, Maria 2024-12-05T21:56:34Z 2024-12-05T21:56:34Z 2020-09-30T07:22:29Z2020-09-30T07:22:29Z20202020-09-30T07:22:29Z http://hdl.handle.net/10459.1/69571 Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches either in outbred pigs or in Babraham large white inbred pigs, which are 85% identical by genome wide SNP analysis. On the other hand, some class II SLA epitopes were recently described in outbred pigs. In this work, Babraham large white inbred pigs were selected to identify SLA II epitopes from SwIV H1N1. PBMCs were screened for recognition of overlapping peptides covering the NP and M1 proteins from heterologous IAV H1N1 in IFNγ ELISPOT. A novel SLA class II restricted epitope was identified in NP from swine H1N1. This conserved novel epitope could be the base for further vaccine approaches against H1N1 in pigs.The research leading to these results has received funding from the European Community's Seventh Framework Program (FP7, 2007-2013), the Research Infrastructures Action under grant FP7-228393 (a NADIR project); from the project AGL2010-22200-C02-01 from the Spanish Ministry of Science and Innovation; the UK's BBSRC grant BBS/E/I/00002014. cc-by (c) Baratelli, Massimiliano et al., 2020 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ Swine influenza Class II epitopes Swine Nucleoprotein Identification of a newly conserved SLA-II epitope in a structural protein of swine influenza virus info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion