2026-04-18T03:44:06Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/675202024-12-05T22:21:49Zcom_2072_3622col_2072_479130

Mitochondrial calcium signaling and neurodegenerative diseases Britti, Elena Delaspre, Fabien Tamarit Sumalla, Jordi Ros Salvador, Joaquim Sistema nerviós -- Degeneració Calci Mitocondris Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA). This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad [grant number SAF2017-83883-R]; and the Ataxia U.K./Ireland and ACAH for supporting our lab. 2024-12-05T22:21:48Z 2024-12-05T22:21:48Z 2024-12-05T22:21:48Z 2019-11-12T09:40:01Z 2019-11-12T09:40:01Z 2018-11-16 2019-11-12T09:40:01Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10459.1/67520 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83883-R/ES/TARGETING MITOCHONDRIA IN FRIEDREICH ATAXIA: MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES/ Reproducció del document publicat a https://doi.org/10.1042/NS20180061 Neuronal signaling, 2018, vol. 2, núm. 4, p. NS20180061 cc-by (c) Elena Britti et al., 2018 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Portland Press