2026-04-14T07:07:19Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/675202024-12-05T22:21:49Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Britti, Elena author Delaspre, Fabien author Tamarit Sumalla, Jordi author Ros Salvador, Joaquim author 2019-11-12T09:40:01Z 2019-11-12T09:40:01Z 2018-11-16 2019-11-12T09:40:01Z Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA). This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad [grant number SAF2017-83883-R]; and the Ataxia U.K./Ireland and ACAH for supporting our lab. http://hdl.handle.net/10459.1/67520 Sistema nerviós -- Degeneració Calci Mitocondris Mitochondrial calcium signaling and neurodegenerative diseases