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oai:recercat.cat:10459.1/652172024-12-05T22:50:34Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Baratelli, Massimiliano author Córdoba, Lorena author Perez, Lester Josue author Maldonado, Jaime author Fraile Sauce, Lorenzo José author Núñez, José I. author Montoya, Maria author 2018-11-29T08:53:25Z 2018-11-29T08:53:25Z 2014 2018-11-29T08:53:25Z Swine influenza virus is one of the most important pathogens involved in the swine respiratory disease complex. Recent serological surveys showed a high prevalence of swine influenza strains belonging to the H1N1, H1N2 and H3N2 subtypes circulating in pigs in Spain. However, little is known about their genome sequence. Five swine influenza strains were isolated from some unrelated outbreaks occurred during 2006–2007, and their complete genome sequences were determined. Phylogenetic analysis revealed that they belonged to the lineages “Avian-Like” H1N1, “Human-Like” H3N2, and “Human-Like” H1N2, showing tight relationships with early or contemporary strains described in Europe. Notably, one virus of the H1N2 subtype showed genetic and antigenic divergence with the European contemporary strains or vaccinal strains of the same subtype, suggesting that some local and divergent clusters of the virus may pass unnoticed in routinary subtyping. Finally, analysis on the entire pattern of genome segments suggested that a second reassortment event could have influenced the evolution of that divergent H1N2 strain. This work was funded by the Project AGL2010-22200-C01 by the Spanish Government. Ph.D. study of Baratelli Massimiliano is funded by a doctoral FPI grant of Spanish Ministry of Science and Innovation. http://hdl.handle.net/10459.1/65217 Spain Swine influenza A virus Sequencing Porcs--Malalties Porcs--Virosis--Espanya Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007