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oai:recercat.cat:10459.1/634722024-12-05T22:31:35Zcom_2072_3622col_2072_479130

Sequence variation in the cathepsin B (CTSB), L (CTSL), S (CTSS) and K (CTSK) genes in Ukrainian pig breeds Balatsky, Viktor Pochernyaev, Konstantin F. Buslyk, Tetyana Dykan, Olena S. Korinnyi, Sergii Pena i Subirà, Ramona Natacha Doran, Olena gens candidats Genètica animal Genética molecular produccio animal Pig Ukrainian breeds Cathepsin genes Polymorphism frequency, Cathepsins are a family of peptidase enzymes which are involved in the regulation of economically important traits in pigs. The aims of this study were (i) to identify the breed-specific frequency of polymorphisms in the cathepsin B (CTSB), L (CTSL), S (CTSS), and K (CTSK) genes in seven Ukrainian pig breeds, and (ii) to compare the cathepsins polymorphism frequency between Ukrainian breeds, a commonly used European meat breed (Piétrain) and a representative fat breed (Meishan). The Ukrainian breeds used were: Ukrainian Large White, Ukrainian Large Black, Poltava Meat, Myrgorod, Ukrainian Steppe Spotted, Ukrainian Landrace and Ukrainian Steppe White. The study established breed-specific differences in the allele frequencies and informativity of polymorphisms in the CTSB, CTSL, CTSS and CTSK genes in Ukrainian breeds. The following were of particular interest: locus CTSB in Ukrainian Large Black breed, locus CTSL in Ukrainian Steppe Spotted, and loci CTSS and CTSK in Myrgorod breed. The segregation of SNPs in meat quality candidate genes demonstrating intermediate or high polymorphism levels in the Ukrainian breeds Myrgorod, Ukrainian Steppe Spotted and Ukrainian Large Black is of interest for future evaluation in association studies with the view of complementing selection indexes with molecular information This research was supported by a research grant from the National Academy of Agricultural Sciences, Ukraine ( No D Р 0111 U004024 ), EU Marie Curie International Research Staff Exchange Grant “Excelmeat” (No 246760) and Biotechnology and Biological Sciences Research Council Pathfinder grant (No BB/FOF/PF/5/11). 2018-06-05T07:24:33Z 2018-06-05T07:24:33Z 2015-02-11 2018-06-05T07:24:33Z info:eu-repo/semantics/article PublishedVersion 2408-5502 http://hdl.handle.net/10459.1/63472 http://hdl.handle.net/10459.1/63472 eng Reproducció del document publicat a: http://www.globalscienceresearchjournals.org/gjabg/954032015057.pdf?view-type=inline Global Journal of Animal Breeding and Genetics, 2015, vol. 3, núm. 3, p. 117-124 info:eu-repo/grantAgreement/EC/FP7/246760 cc-by (c) Global Science Research Journals, 2015 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ application/pdf Global Science Research Journals