2026-04-05T12:42:30Zhttps://recercat.cat/oai/request
oai:recercat.cat:10459.1/632602024-12-05T22:01:29Zcom_2072_3622col_2072_479130
RECERCAT author Carbonell, Marc author Castelblanco Echavarría, Esmeralda author Valldeperas, Xavier author Betriu i Bars, M. Àngels author Traveset Maeso, Alicia author Granado Casas, Minerva author Hernández García, Marta author Vázquez, Federico author Martín, Mariona author Rubinat, Esther author Lecube Torelló, Albert author Franch-Nadal, Josep author Fernández i Giráldez, Elvira author Puig-Domingo, Manuel author Avogaro, Angelo author Alonso, Núria author Mauricio Puente, Dídac 2024-12-05T22:01:29Z 2024-12-05T22:01:29Z 2018-05-09T11:04:20Z2018-05-09T11:04:20Z2018-05-042018-05-09T11:04:23Z http://hdl.handle.net/10459.1/63260 Background: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results: In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions: In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.This research was supported by grants from the Spanish Ministry of Health, the Carlos III National Institute of Health (PI12/0183 and PI15/0625) and European Regional Development Fund (ERDF). CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative of ISCIII, Spain. cc-by (c) Carbonell, Marc et al., 2018 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es Diabetis Retinopatia diabètica Aterosclerosi Diabetes Diabetic retinopathy Atherosclerosis Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion