2026-04-13T01:22:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/484522024-12-05T21:23:13Zcom_2072_3622col_2072_479130

Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort Estrada, Vicente Geijo, Paloma Fuentes Ferrer, Manuel García Alcalde, María Luisa Rodrigo, María Galindo, María José Muñoz, Agustín Domingo, Pere Ribera, Esteve Cosín, Jaime Viciana, Pompeyo Lozano, Fernando Terrón, Alberto Vergara, Antonio Teira, Ramón Muñoz Sánchez, Josefa Roca, Bernardino Sánchez, Trinitario López Aldeguer, José Deig, Elisabeth Vidal, Francisco Pedrol, Enric Castaño Carracedo, Manuel Puig, Teresa Garrido, Myriam Suárez Lozano, Ignacio Background: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio. 2015-07-09T10:04:13Z 2015-07-09T10:04:13Z 2011 article publishedVersion https://doi.org/10.1186/1472-6874-11-36 1472-6874 http://hdl.handle.net/10459.1/48452 http://hdl.handle.net/10459.1/48452 eng Reproducció del document publicat a https://doi.org/10.1186/1472-6874-11-36 BMC Women’s Health, 2011, vol. 11, núm. 36, p. 1-8 cc-by, (c) Estrada et al., 2011 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es/ BioMed Central