2026-04-17T23:15:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/4642432025-09-15T18:08:07Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Martín Masot, Rafael author Jiménez-Muñoz, María author Herrador-López, Marta author Navas-López, Víctor Manuel author Obis Monné, Èlia author Jové Font, Mariona author Pamplona Gras, Reinald author Nestares, Teresa author 2023 Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors. Despite a growing understanding of the pathophysiological mechanisms of the disease, diagnosis is still often delayed and there are no effective biomarkers for early diagnosis. The only current treatment, a gluten-free diet (GFD), can alleviate symptoms and restore intestinal villi, but its cellular effects remain poorly understood. To gain a comprehensive understanding of CD’s progression, it is crucial to advance knowledge across various scientific disciplines and explore what transpires after disease onset. Metabolomics studies hold particular significance in unravelling the complexities of multifactorial and multisystemic disorders, where environmental factors play a significant role in disease manifestation and progression. By analyzing metabolites, we can gain insights into the reasons behind CD’s occurrence, as well as better comprehend the impact of treatment initiation on patients. In this review, we present a collection of articles that showcase the latest breakthroughs in the field of metabolomics in pediatric CD, with the aim of trying to identify CD biomarkers for both early diagnosis and treatment monitoring. These advancements shed light on the potential of metabolomic analysis in enhancing our understanding of the disease and improving diagnostic and therapeutic strategies. More studies need to be designed to cover metabolic profiles in subjects at risk of developing the disease, as well as those analyzing biomarkers for follow-up treatment with a GFD. This research was funded by the FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades Projects FEDER No B-AGR-658 and Excelencia P21_00101. It was also partially funded with the grant “Investigation grant program by the Association of Celiacs and Sensitive to Gluten of the Community of Madrid” and the Government of Catalonia: Agency for the Management of University and Resarch Grants (2021SGR00990). María Jiménez-Muñoz is grateful to the Ph.D. program “Nutrición y Ciencias de los Alimentos” from the University of Granada Celiac disease Gluten-free diet Metabolomics Children Immune Intestinal Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet