2026-04-13T02:05:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:10459.1/4641312025-09-15T18:40:51Zcom_2072_3622col_2072_479130

00925njm 22002777a 4500 dc Serrano Casasola, José Carlos Enrique author Castro-Boqué, Eva author García-Carrasco, Alicia author Morán-Valero, María Inés author González-Hedström, Daniel author Bermúdez López, Marcelino author Valdivielso Revilla, José Manuel author Espinel, Alberto E. author Portero Otín, Manuel author 2023 The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerability, such as the aging process at controlled temperature and humidity. This study aims to validate the antihypertensive effects of an optimized extract of aged black garlic with low doses of s-allyl-cysteine (SAC) in a Grade I hypertensive population with drug treatment. A randomized, triple-blind, placebo-controlled parallel trial was developed, where a daily supplementation with 0.25 mg/day of SAC for 12 weeks was performed. A reduction in systolic and diastolic blood pressure of 1.8 mmHg (0.7 to 4.1 95% CI) and 1.5 mmHg (0.3 to 3.0 95% CI), respectively, was observed. Similarly, an increase in blood nitric oxide (10.3 µM, 1.1 to 19.5 95% CI) and antioxidant capacity (7 × 10−3 µM TE/min, (1.2 to 13 × 10−3 95% CI) and a reduction in uric acid levels (−0.3 mg/dL, −0.5 to −0.001 95% CI) and ACE activity (−9.3 U/L; −18.4 to −0.4 95% CI) were observed. No changes in endothelial function and inflammatory cytokines were observed. It was concluded that low-dose SAC supplementation in an optimized black-garlic extract allows for an extra-significant reduction in blood pressure in a Grade I hypertensive population receiving drug treatment. Hypertension Aged black garlic Blood pressure S-allyl-cysteine Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial