2026-04-18T00:33:12Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/274882025-10-06T23:48:28Zcom_2072_452955com_2072_2054col_2072_452960col_2072_453079

Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study Vilalta Lacarra, Anna Vilalta Franch, Joan Serrano Sarbosa, Domènec Martí Lluch, Ruth Marrugat, Jaume Garre Olmo, Josep Depressió psíquica Depression, Mental Càncer -- Mortalitat Cancer -- Mortality Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort. Methods: A community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality. Results: The cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11–4.44) and women (HR = 3.69; 95% CI = 1.69–8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46–3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10–6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76–4.90) only in the male population. Conclusion: C-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality. This study was supported by the research grant STL006/17/00234 from the Strategic Plan for Health Research and Innovation (PERIS) 2016–2020 of the Department of Health, Government of Catalonia 2023-08-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/27488 37711322 PMC10497951 http://hdl.handle.net/10256/27488 eng info:eu-repo/semantics/altIdentifier/doi/10.3389/fpsyg.2023.1192462 info:eu-repo/semantics/altIdentifier/eissn/1664-1078 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Frontiers Media Frontiers in Psychology, 2023, vol. 14, art. núm. 1192462 Articles publicats (D-CM)