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oai:recercat.cat:10256/273532025-09-27T14:28:54Zcom_2072_452955com_2072_2054col_2072_453072

The Predictive Value of Emotion Regulation in Cocaine Use Disorder Severity: Psychotherapeutic Implications During Hospitalization for Detoxification Palazón Llecha, Alba Trujols i Albet, Joan Madre, Mercè Duran Sindreu, Santiago Batlle, Francesca Mallorquí Bagué, Núria Cocaïnomania Cocaine abuse Síndrome d'abstinència Drugs withdrawal symptoms Cocaïna -- Aspectes psicològics Cocaine -- Psychological aspects Objective: Traditional treatment approaches in cocaine use disorder (CUD) still report high rates of poor outcomes. Emotion regulation (ER) is a transdiagnostic factor that may contribute to the initiation and maintenance of CUD, strengthening addiction severity. A deeper understanding of ER in this population is crucial for improving treatment outcomes. This study explores whether ER difficulties at treatment entry predict addiction severity and withdrawal symptom severity after discharge in patients with CUD. Secondarily, it examines whether withdrawal symptom severity mediates the relationship between ER difficulties and relapse. Methods: A total of 70 CUD patients underwent a 14-day inpatient detoxification. At admission, cocaine use-related variables and ER questionnaires (DERS and ERQ) were registered. After discharge, addiction severity (SDS), craving (WCS), cocaine withdrawal symptom severity (CSSA) and relapse were recorded. Multiple linear regression and mediation analysis were conducted to address the primary and secondary aims, respectively. This study draws on data from a larger randomized clinical trial. Results: Impulse control difficulties and nonacceptance of emotional responses predicted SDS, and nonacceptance of emotional responses predicted CSSA. However, mediation analyses showed no indirect effect of DERS total score on relapse through the effect of the mediating variable CSSA. Conclusion: ER screening at hospitalization admission may optimize treatment by identifying high-risk CUD patients. Third-generation therapies targeting ER skills may enhance outcomes by helping patients manage emotional distress, potentially reducing addiction severity and withdrawal symptoms. Because of mixed results and the exploratory nature of this study, further research on the ER role in this context is needed Research funding: Instituto de Salud Carlos III. Grant Number: PI20/00929; European Regional Development Fund; Instituto Carlos III and Fundació Privada Hospital de la Santa Creu i Sant Pau. Open Access fundingprovided thanks to the CRUE- CSIC agreement with Wiley Open Access funding provided thanks to the CRUE-CSIC agreement with Wiley 2025-09-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/27353 40983318 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/cpp.70155 info:eu-repo/semantics/altIdentifier/issn/1063-3995 info:eu-repo/semantics/altIdentifier/eissn/1099-0879 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley Clinical Psychology & Psychotherapy, 2025, vol. 32, núm. 5, p. e70155 Articles publicats (D-PS)