2026-04-14T08:40:50Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/268362025-05-29T00:05:53Zcom_2072_452955com_2072_2054col_2072_453073

Dehydrogenative Coupling Reaction for the Synthesis of 5- and 6-Heterocyclic Derivatives Catalyzed by Earth-Abundant Metal-Based Complexes Joly, Nicolas Mauclaire, Clara Gaillard, Sylvain Poater Teixidor, Albert Renaud, Jean Luc Agencia Estatal de Investigación Reaccions químiques Chemical reactions Deshidrogenació Dehydrogenation Heterocycle synthesis is an intense research area due to their significant importance in pharmaceutical, material chemistry and fine synthesis. Key innovations include transition metal-based-catalyzed heterocyclic derivatives synthesis, which facilitates diverse structural modifications, enhances selectivities and efficiency. The necessity to develop more greener technologies for the construction of new C−C and C−N bonds has strived chemists to re-design their synthetic strategy plan and to introduce abundant starting materials. Among these new transformations, acceptorless dehydrogenative coupling (ADC) reactions have received increased attention thanks to their atom-economy, the use of alcohols as pro-electrophiles and the formation of water and hydrogen gas as only by-products. These methods exemplify the interplay between traditional and cutting-edge techniques, providing a robust synthetic toolkit to address the growing demand for biologically relevant compounds with tailored functionalities. This review will focus on the acceptorless dehydrogenative coupling methodologies for the synthesis of nitrogen-containing 5- and 6-membered heterocyclic derivatives (such as pyrroles, pyrimidines, quinazolines, and quinoxalines) in the presence of 3d-metal complexes. The state of the art of the ADC process underscores the continuous evolution of synthetic strategies and emphases its importance in creating valuable and structurally diverse compounds, ensuring their centrality in both academic and pharmaceutical research We gratefully acknowledge financial support from the “Ministère de la Recherche et des Nouvelles Technologies”, Normandie Université, University of Caen Normandie, CNRS, “Région Normandie”, the LABEX SynOrg (ANR-11-LABEX-0029), and European Union (HORIZON-MSCA-2022-DN-01 Project: 101119574). C. M. thanks Sorbonne University Alliance for a PhD grant. We thank the Spanish Ministerio de Ciencia e Innovación for project PID2021-127423NB-I00 and the Generalitat de Catalunya for project 2021SGR623 Open Access funding provided thanks to the CRUE-CSIC agreement with Wiley 2025-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/26836 http://hdl.handle.net/10256/26836 eng info:eu-repo/semantics/altIdentifier/doi/10.1002/ajoc.202400728 info:eu-repo/semantics/altIdentifier/issn/2193-5807 info:eu-repo/semantics/altIdentifier/eissn/2193-5815 PID2021-127423NB-I00 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127423NB-I00/ES/CATALISIS PREDICTIVA PARA CAMBIAR EL ODEN SECUENCIAL ENTRE EXPERIMENTOS I CALCULOS/ Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley Asian Journal of Organic Chemistry, 2025, vol. 14, núm.5, p. e202400728 Articles publicats (D-Q)