2026-04-17T12:49:18Zhttps://recercat.cat/oai/request
oai:recercat.cat:10256/250502024-10-29T16:14:10Zcom_2072_452955com_2072_2054col_2072_452960
RECERCAT author Fagundo, Ana B. author Torre, Rafael de la author Jiménez-Murcia, Susana author Agüera, Zaida author Pastor, Antoni author Casanueva, Felipe F. author Granero, Roser author Baños, Rosa M. author Botella, Cristina author Pino Gutiérrez, Amparo del author Fernández-Real Lemos, José Manuel author Fernández García, Jose C. author Frühbeck, Gema author Gómez Ambrosi, Javier author Menchón Magriñá, José Manuel author Moragrega Vergara, Inés author Rodríguez, Roser author Tárrega, Salomé author Tinahones, Francisco J. author Fernández Aranda, Fernando 2024-10-29T16:14:10Z 2024-10-29T16:14:10Z 2013-06-19 http://hdl.handle.net/10256/25050 Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Funcions executives (Neuropsicologia) Executive functions (Neuropsychology) Cannabinoides Cannabinoids Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed