2026-04-14T02:54:14Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/235292025-04-30T23:48:04Zcom_2072_452955com_2072_2054col_2072_453069

00925njm 22002777a 4500 dc Palarea Albaladejo, Javier author McNeilly, Tom N. author Nisbet, Alasdair J. author 2024-02 This work discusses and demonstrates the novel use of multivariate analysis and data dimensionality reduction techniques to handle the variety and complexity of data generated in efficacy trials for the development of a prototype vaccine to protect sheep against the Teladorsagia circumcincta nematode. A curated collection of data dimension reduction and visualisation techniques, in conjunction with sensible statistical modelling and testing which explicitly model key features of the data, offers a synthetic view of the relationships between the multiple biological parameters measured. New biological insight is gained into the patterns and associations involving antigen-specific antibody levels, antibody avidity and parasitological parameters of efficacy that is not achievable by standard statistical practice in the field. This approach can therefore be used to guide vaccine refinement and simplification through identifying the most immunologically relevant antigens, and it can be analogously implemented for similar studies in other areas. To facilitate this, the associated data and computer codes written for the R open system for statistical computing are made freely available The authors gratefully acknowledge funding for this project from Scottish Government Rural & Environment Science & Analytical Services (RESAS) and from the BBSRC, award number BB/L027186/1. We acknowledge funding from the European Union’s Horizon 2020 Research and Innovation Programme (Grant Number: 635408). Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature Anàlisi multivariable Multivariate analysis Ovelles -- Paràsits Sheep -- Parasites Vacunes veterinàries Veterinary vaccines A curated multivariate approach to study efficacy and optimisation of a prototype vaccine against teladorsagiasis in sheep