2026-04-17T20:38:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/228462024-06-18T12:42:11Zcom_2072_452955com_2072_2054col_2072_453079

The global deterioration scale for Down syndrome population (GDS-DS): a rating scale to assess the progression of Alzheimer's disease Rodríguez-Hidalgo, Emili García-Alba, Javier Novell, Ramon Esteba Castillo, Susanna Trastorns de la cognició Demència Down, Síndrome de Cognition disorders Dementia Down syndrome Alzheimer, Malaltia d' Alzheimer's disease Discapacitat intel·lectual Intellectual disability The aim of this study is to adapt and validate the global deterioration scale (GDS) for the systematic tracking of Alzheimer’s disease (AD) progression in a population with Down syndrome (DS). A retrospective dual-center cohort study was conducted with 83 participants with DS (46.65 ± 5.08 years) who formed the primary diagnosis (PD) group: cognitive stability (n = 48), mild cognitive impairment (n = 24), and Alzheimer’s disease (n = 11). The proposed scale for adults with DS (GDS-DS) comprises six stages, from cognitive and/or behavioral stability to advanced AD. Two neuropsychologists placed the participants of the PD group in each stage of the GDS-DS according to cognitive, behavioral and daily living skills data. Inter-rater reliability in staging with the GDS-DS was excellent (ICC = 0.86; CI: 0.80–0.93), and the agreement with the diagnosis categories of the PD group ranged from substantial to excellent with κ values of 0.82 (95% CI: 0.73–0.92) and 0.85 (95% CI: 0.72, 0.99). Performance with regard to the CAMCOG-DS total score and orientation subtest of the Barcelona test for intellectual disability showed a slight progressive decline across all the GDS-DS stages. The GDS-DS scale is a sensitive tool for staging the progression of AD in the DS population, with special relevance in daily clinical practice This research was funded by the Spanish Government, grant number PI12/02019, PSI-2014-53524-P. The APC was funded by S.E.-C,’s SESMDI research start-up funds 2023-03-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/22846 http://hdl.handle.net/10256/22846 eng info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph20065096 info:eu-repo/semantics/altIdentifier/issn/1661-7827 info:eu-repo/semantics/altIdentifier/eissn/1660-4601 Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI (Multidisciplinary Digital Publishing Institute) International Journal of Environmental Research and Public Health, 2023, vol. 20, núm. 6, p. 5096 Articles publicats (IdIBGi) Rodríguez-Hidalgo, Emili García-Alba, Javier Novell, Ramon Esteba Castillo, Susanna 2023 The global deterioration scale for Down syndrome population (GDS-DS): a rating scale to assess the progression of Alzheimer's disease International Journal of Environmental Research and Public Health 20 6 5096