2026-04-13T04:55:18Zhttps://recercat.cat/oai/requestoai:recercat.cat:10256/223272024-06-18T12:18:52Zcom_2072_452955com_2072_2054col_2072_453069
RECERCAT
author
Vives Mestres, Marina
author
Casanova, Amparo
author
Puig Oriol, Xavier
author
Ginebra, Josep
author
Rosen, Noah
2024-06-18T12:18:52Z
2024-06-18T12:18:52Z
2022-12-13
http://hdl.handle.net/10256/22327
Objective
To assess whether alcohol intake is associated with the onset of migraine attacks up to 2 days after consumption in individuals with episodic migraine (EM).
Background
Although alcohol has long been suspected to be a common migraine trigger, studies have been inconclusive in proving this association.
Methods
This was an observational prospective cohort study among individuals with migraine who registered to use a digital health platform for headache. Eligible individuals were aged ≥18 years with EM who consumed alcohol and had tracked their headache symptoms and alcohol intake for ≥90 days. People who did not drink any alcohol were excluded. The association of alcohol intake (“Yes/No”) and of the number of alcoholic beverages in the 2 days preceding a migraine attack was assessed accounting for the presence of migraine on day-2 and its interaction with alcohol intake on day-2, and further adjusted for sex, age, and average weekly alcohol intake.
Results
Data on 487 individuals reporting 5913 migraine attacks and a total of 40,165 diary days were included in the analysis. Presence of migraine on day-2 and its interaction with alcohol intake on day-2 were not significant and removed from the model. At the population level, alcohol intake on day-2 was associated with a lower probability of migraine attack (OR [95% CI] = 0.75 [0.68, 0.82]; event rate 1006/4679, 21.5%), while the effect of alcohol intake on day-1 was not significant (OR [95% CI] = 1.01 [0.91, 1.11]; event rate 1163/4679, 24.9%) after adjusting for sex, age, and average weekly alcohol intake. Similar results were obtained with the number of beverages as exposure.
Conclusions
In this English-speaking cohort of individuals with EM who identified themselves as mostly low-dose alcohol consumers, there was no significant effect on the probability of a migraine attack in the 24 h following consumption, and a slightly lower likelihood of a migraine attack from 24 to 48 h following useOpen Access funding provided thanks to the CRUE-CSIC agreement with Wiley
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Consum d'alcohol
Drinking of alcoholic beverages
Migranya -- Mètode longitudinal
Migraine -- Longitudinal method
Alcohol as a trigger of migraine attacks in people with migraine. Results from a large prospective cohort study in English-speaking countries
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed