2026-04-17T17:29:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/217572025-03-12T09:29:45Zcom_2072_452955com_2072_2054col_2072_453079

00925njm 22002777a 4500 dc Peracaula Domínguez, Míriam author Torres, Daniela author Poyatos Dorado, Paula author Luque, Neus author Rojas, Eric author Obrador, Anton author Orriols Martínez, Ramon author Tura-Ceide, Olga author 2022-04-05 Obstructive sleep apnea (OSA) is a respiratory condition during sleep caused by repeated pauses in breathing due to upper airway obstruction. It is estimated that OSA affects 30% of the population, but only 10% are well diagnosed due to the absence of a well-defined symptomatology and poor screening tools for early diagnosis. OSA is associated to an endothelial dysfunction inducing several biological responses such as hypoxia, hypercapnia and oxidative stress, among others. OSA also triggers respiratory, nervous, metabolic, humoral and immunity system activations that increase the possibility of suffering a cardiovascular (CV) disease. In this review, we expose different studies that show the relationship between OSA and endothelial dysfunction and its association with CV pathologies like hypertension, and we define the most well-known treatments and their limitations. Additionally, we describe the potential future directions in OSA research, and we report clinical features such as endothelial progenitor cell alterations that could act as biomarkers for the development of new diagnostic tools and target therapies Síndromes d'apnea del son Sleep apnea syndromes Sistema cardiovascular -- Malalties Cardiovascular system -- Diseases Cèl·lules endotelials Endothelial cells Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article