2026-04-14T06:13:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/207852024-06-18T12:41:36Zcom_2072_452955com_2072_2054col_2072_453079

Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology Cuyàs, Elisabet Verdura, Sara Martin Castillo, Begoña Menéndez Menéndez, Javier Abel Metformina Epigenètica Càncer Metformin Epigenetics Cancer Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic biguanide metformin. Here, we briefly review how metabolite-derived chromatin modifications and the metabolo-epigenetic machinery itself are both amenable to modification by metformin in a local and a systemic manner. First, we consider the capacity of metformin to target global metabolic pathways or specific metabolic enzymes producing chromatin-modifying metabolites. Second, we examine its ability to directly or indirectly fine-tune the activation status of chromatin-modifying enzymes. Third, we envision how the interaction between metformin, diet and gut microbiota might systemically regulate the metabolic inputs to chromatin. Experimental and clinical validation of metformin's capacity to change the functional outcomes of the metabolo-epigenetic link could offer a proof-of-concept to therapeutically test the metabolic adjustability of the epigenomic landscape of cancer 2021-02-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/20785 http://hdl.handle.net/10256/20785 eng info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2020.620641 info:eu-repo/semantics/altIdentifier/eissn/2234-943X Reconeixement 4.0 Internacional http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess application/pdf Frontiers Media Frontiers in Oncology, 2021, vol. 10, art.núm.620641 Articles publicats (IdIBGi) Cuyàs, Elisabet Verdura, Sara Martin Castillo, Begoña Menéndez Menéndez, Javier Abel 2021 Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology Frontiers in Oncology 10 art.núm.620641