2026-04-17T02:55:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/194702024-06-18T11:54:08Zcom_2072_452955com_2072_2054col_2072_453077

00925njm 22002777a 4500 dc Marano, Roberto B.M. author Fernandes, Telma author Manaia, Célia M. author Nunes, Olga C. author Morrison, Donald author Berendonk, Thomas U. author Kreuzinger, Norbert author Telson, Tanel author Corno, Gianluca author Fatta-Kassinos, Despo author Merlin, Christophe author Topp, Edward author Jurkevitch, Edouard author Henn, Leonie author Scott, Andrew author Heß, Stefanie author Slipko, Katarzyna author Laht, Mailis author Kisand, Veljo author Di Cesare, Andrea author Karaolia, Popi author Michael, Stella G. author Petre, Alice L. author Rosal, Roberto author Pruden, Amy author Riquelme, Virginia author Agüera, Ana author Esteban, Belen author Luczkiewicz, Aneta author Kalinowska, Agnieszka author Leonard, Anne author Gaze, William H. author Adegoke, Anthony A. author Stenstrom, Thor A. author Pollice, Alfieri author Salerno, Carlo author Schwermer, Carsten U. author Krzeminski, Pawel author Guilloteau, Hélène author Donner, Erica author Drigo, Barbara author Libralato, Giovanni author Guida, Marco author Bürgmann, Helmut author Beck, Karin author Garelick, Hemda author Tacão, Marta author Henriques, Isabel author Martínez-Alcalá, Isabel author Guillén-Navarro, Jose M. author Popowska, Magdalena author Piotrowska, Marta author Quintela-Baluja, Marcos author Bunce, Joshua T. author Polo-López, Maria I. author Nahim–Granados, Samira author Pons, Marie Noëlle author Milakovic, Milena author Udikovic-Kolic, Nikolina author Ory, Jérôme author Ousmane, Traore author Caballero, Pilar author Oliver, Antoni author Rodríguez Mozaz, Sara author Balcázar, José Luis author Jäger, Thomas author Schwartz, Thomas author Yang, Ying author Zou, Shichun author Lee, Yunho author Yoon, Younggun author Herzog, Bastian author Mayrhofer, Heidrun author Prakash, Om author Nimonkar, Yogesh author Heath, Ester author Baraniak, Anna author Abreu-Silva, Joana author Choudhury, Manika author Munoz, Leonardo P. author Krizanovic, Stela author Brunetti, Gianluca author Maile-Moskowitz, Ayella author Brown, Connor author Cytryn, Eddie author 2020-11-01 The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (<0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 103 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status http://hdl.handle.net/10256/19470 Aigües residuals -- Plantes de tractament Sewage disposal plants Microorganismes -- Resistència als medicaments Drug resistance in microorganisms Aigua -- Reutilització Water reuse A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants