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oai:recercat.cat:10256/182622024-12-18T04:16:09Zcom_2072_452955com_2072_2054col_2072_453079

Shared heritability and functional enrichment across six solid cancers Jiang, Xia Finucane, Hilary K. Schumacher, Fredrick R. Schmit, Stephanie L. Tyrer, Jonathan P. Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B. Dennis, Joe Conti, David V. Casey, Graham Gaudet, Mia M. Huyghe, Jeroen R. Albanes, Demetrius Aldrich, Melinda C. Andrew, Angeline S. Andrulis, Irene L. Anton-Culver, Hoda Antoniou, Antonis C. Antonenkova, Natalia N. Arnold, Susanne M. Aronson, Kristan J. Arun, Banu K. Bandera, Elisa V. Barkardottir, Rosa B. Barnes, Daniel R. Batra, Jyotsna Beckmann, Matthias W. Benítez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I. Bickeböller, Heike Bien, Stephanie A. Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brenton, James D. Brook, Mark N. Brunet i Vidal, Joan Brunnström, Hans Buchanan, Daniel D. Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldés, Trinidad Caligo, Maria A. Campbell, Ian Campbell, Peter T. Cancel-Tassin, Géraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, André L. Chan, Andrew T. Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Christiani, David C. Claes, Kathleen B. M. Claessens, Frank Clements, Judith Collée, J. Margriet Correa, Marcia Cruz Couch, Fergus J. Cox, Angela Cunningham, Julie M. Cybulski, Cezary Czene, Kamila Daly, Mary B. Fazio, Anna de Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L. Dörk, Thilo Duell, Eric J. Dunning, Alison M. Dwek, Miriam Eccles, Diana M. Edlund, Christopher K. Vélez Edwards, Digna R. Ellberg, Carolina Evans, D. Gareth Fasching, Peter A. Ferris, Robert L. Liloglou, Triantafillos Figueiredo, Jane C. Fletcher, Olivia Fortner, Renée T. Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J. Ganz, Patricia A. Garber, Judy García Sáenz, José Ángel Gayther, Simon A. Giles, Graham G. Godwin, Andrew K. Goldberg, Mark S. Goldgar, David E. Goode, Ellen L. Goodman, Marc T. Goodman, Gary Grankvist, Kjell Greene, Mark H. Gronberg, Henrik Gronwald, Jacek Guénel, Pascal Håkansson, Niclas Hall, Per Hamann, Ute Hamdy, Freddie C. Hamilton, Robert J. Hampe, Jochen Haugen, Aage Heitz, Florian Herrero, Rolando Hillemanns, Peter Hoffmeister, Michael Høgdall, Estrid Hong, Yun-Chul Hopper, John L. Houlston, Richard Hulick, Peter J. Hunter, David J. Huntsman, David G. Idos, Gregory Imyanitov, Evgeny N. Ingles, Sue Ann Isaacs, Claudine Jakubowska, Anna James, Paul Jenkins, Mark A. Johansson, Mattias Johansson, Mikael John, Esther M. Joshi, Amit D. Kaneva, Radka Karlan, Beth Y. Kelemen, Linda E. Kühl, Tabea Khaw, Kay-Tee Khusnutdinova, Elza Kibel, Adam S. Kiemeney, Lambertus A. Kim, Jeri Kjaer, Susanne K. Knight, Julia A. Kogevinas, Manolis Kote-Jarai, Zsofia Koutros, Stella Kristensen, Vessela N. Kupryjanczyk, Jolanta Lacko, Martin Lam, Stephan Lambrechts, Diether Landi, Maria Teresa Lazarus, Philip Le, Nhu D. Lee, Eunjung Lejbkowicz, Flavio Lenz, Heinz-Josef Leslie, Goska Lessel, Davor Lester, Jenny Levine, Douglas A. Li, Li Li, Christopher I. Lindblom, Annika Lindor, Noralane M. Liu, Geoffrey Loupakis, Fotios Lubiński, Jan Maehle, Lovise Maier, Christiane Mannermaa, Arto Marchand, Loic Le Margolin, Sara May, Taymaa McGuffog, Lesley Meindl, Alfons Middha, Pooja Miller, Austin Milne, Roger L. MacInnis, Robert J. Modugno, Francesmary Montagna, Marco Moreno, Victor Moysich, Kirsten B. Mucci, Lorelei Muir, Kenneth Mulligan, Anna Marie Nathanson, Katherine L. Neal, David E. Ness, Andrew R. Neuhausen, Susan L. Nevanlinna, Heli Newcomb, Polly A. Newcomb, Lisa F. Nielsen, Finn Cilius Nikitina-Zake, Liene Nordestgaard, Børge G. Nussbaum, Robert L. Offit, Kenneth Olah, Edith Olama, Ali Amin Al Olopade, Olufunmilayo I. Olshan, Andrew F. Olsson, Håkan Osorio, Ana Pandha, Hardev Park, Jong Y. Pashayan, Nora Parsons, Michael T. Pejovic, Tanja Penney, Kathryn L. Peters, Wilbert H M. Phelan, Catherine M. Phipps, Amanda I. Plaseska-Karanfilska, Dijana Pring, Miranda Prokofyeva, Darya Radice, Paolo Stefansson, Kari Ramus, Susan J. Raskin, Leon Rennert, Gad Rennert, Hedy S. Rensburg, Elizabeth J. van Riggan, Marjorie J. Risch, Harvey A. Risch, Angela Roobol, Monique J. Rosenstein, Barry S. Rossing, Mary Anne Ruyck, Kim De Saloustros, Emmanouil Sandler, Dale P. Sawyer, Elinor J. Schabath, Matthew B. Schleutker, Johanna Schmidt, Marjanka K. Setiawan, V. Wendy Shen, Hongbing Siegel, Erin M. Sieh, Weiva Singer, Christian F. Slattery, Martha L. Sorensen, Karina Dalsgaard Southey, Melissa C. Spurdle, Amanda B. Stanford, Janet L. Stevens, Victoria L. Stintzing, Sebastian Stone, Jennifer Sundfeldt, Karin Sutphen, Rebecca Swerdlow, Anthony J. Tajara, Eloiza H. Tangen, Catherine M. García Tardón, Adonina Taylor, Jack A. Teare, M. Dawn Teixeira, Manuel R. Terry, Mary Beth Thibodeau, Stephen N. Thomassen, Mads Bjørge, Line Tischkowitz, Marc Toland, Amanda E. Torres, Diana Townsend, Paul A. Travis, Ruth C. Tung, Nadine Tworoger, Shelley S. Ulrich, Cornelia M. Usmani, Nawaid Vachon, Celine M. Nieuwenhuysen, Els van Vega, Ana Aguado-Barrera, Miguel Elías Wang, Qin Webb, Penelope M. Weinberg, Clarice R. Weinstein, Stephanie Weissler, Mark C. Weitzel, Jeffrey N. West, Catharine M. L. White, Emily Whittemore, Alice S. Wichmann, H-Erich Wiklund, Fredrik Winqvist, Robert Wolk, Alicja Woll, Penella Woods, Michael Wu, Anna H. Wu, Xifeng Yannoukakos, Drakoulis Zheng, Wei Zienolddiny, Shanbeh Ziogas, Argyrios Zorn, Kristin K. Lane, Jacqueline M. Saxena, Richa Thomas, Duncan Hung, Rayjean J. Diergaarde, Brenda McKay, James D. Peters, Ulrike Hsu, Li Garcia-Closas, Montserrat Eeles, Rosalind A. Chenevix-Trench, Georgia Brennan, Paul J. Haiman, Christopher A. Simard, Jacques Easton, Douglas F. Gruber, Stephen B. Pharoah, Paul D. P. Price, Alkes L. Pasaniuc, Bogdan Amos, Christopher I. Kraft, Peter Lindström, Sara Càncer -- Etiologia Cancer -- Etiology Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis 2024-06-18T12:40:58Z 2024-06-18T12:40:58Z 2024-06-18T12:40:58Z 2019-01-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/18262 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-018-08054-4 info:eu-repo/semantics/altIdentifier/issn/2041-1723 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Nature Research Nature Communications, 2019, vol. 10, art. núm. 431 Articles publicats (IdIBGi)