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oai:recercat.cat:10256/182622024-12-18T04:16:09Zcom_2072_452955com_2072_2054col_2072_453079

00925njm 22002777a 4500 dc Jiang, Xia author Finucane, Hilary K. author Schumacher, Fredrick R. author Schmit, Stephanie L. author Tyrer, Jonathan P. author Han, Younghun author Michailidou, Kyriaki author Lesseur, Corina author Kuchenbaecker, Karoline B. author Dennis, Joe author Conti, David V. author Casey, Graham author Gaudet, Mia M. author Huyghe, Jeroen R. author Albanes, Demetrius author Aldrich, Melinda C. author Andrew, Angeline S. author Andrulis, Irene L. author Anton-Culver, Hoda author Antoniou, Antonis C. author Antonenkova, Natalia N. author Arnold, Susanne M. author Aronson, Kristan J. author Arun, Banu K. author Bandera, Elisa V. author Barkardottir, Rosa B. author Barnes, Daniel R. author Batra, Jyotsna author Beckmann, Matthias W. author Benítez, Javier author Benlloch, Sara author Berchuck, Andrew author Berndt, Sonja I. author Bickeböller, Heike author Bien, Stephanie A. author Blomqvist, Carl author Boccia, Stefania author Bogdanova, Natalia V. author Bojesen, Stig E. author Bolla, Manjeet K. author Brauch, Hiltrud author Brenner, Hermann author Brenton, James D. author Brook, Mark N. author Brunet i Vidal, Joan author Brunnström, Hans author Buchanan, Daniel D. author Burwinkel, Barbara author Butzow, Ralf author Cadoni, Gabriella author Caldés, Trinidad author Caligo, Maria A. author Campbell, Ian author Campbell, Peter T. author Cancel-Tassin, Géraldine author Cannon-Albright, Lisa author Campa, Daniele author Caporaso, Neil author Carvalho, André L. author Chan, Andrew T. author Chang-Claude, Jenny author Chanock, Stephen J. author Chen, Chu author Christiani, David C. author Claes, Kathleen B. M. author Claessens, Frank author Clements, Judith author Collée, J. Margriet author Correa, Marcia Cruz author Couch, Fergus J. author Cox, Angela author Cunningham, Julie M. author Cybulski, Cezary author Czene, Kamila author Daly, Mary B. author Fazio, Anna de author Devilee, Peter author Diez, Orland author Gago-Dominguez, Manuela author Donovan, Jenny L. author Dörk, Thilo author Duell, Eric J. author Dunning, Alison M. author Dwek, Miriam author Eccles, Diana M. author Edlund, Christopher K. author Vélez Edwards, Digna R. author Ellberg, Carolina author Evans, D. Gareth author Fasching, Peter A. author Ferris, Robert L. author Liloglou, Triantafillos author Figueiredo, Jane C. author Fletcher, Olivia author Fortner, Renée T. author Fostira, Florentia author Franceschi, Silvia author Friedman, Eitan author Gallinger, Steven J. author Ganz, Patricia A. author Garber, Judy author García Sáenz, José Ángel author Gayther, Simon A. author Giles, Graham G. author Godwin, Andrew K. author Goldberg, Mark S. author Goldgar, David E. author Goode, Ellen L. author Goodman, Marc T. author Goodman, Gary author Grankvist, Kjell author Greene, Mark H. author Gronberg, Henrik author Gronwald, Jacek author Guénel, Pascal author Håkansson, Niclas author Hall, Per author Hamann, Ute author Hamdy, Freddie C. author Hamilton, Robert J. author Hampe, Jochen author Haugen, Aage author Heitz, Florian author Herrero, Rolando author Hillemanns, Peter author Hoffmeister, Michael author Høgdall, Estrid author Hong, Yun-Chul author Hopper, John L. author Houlston, Richard author Hulick, Peter J. author Hunter, David J. author Huntsman, David G. author Idos, Gregory author Imyanitov, Evgeny N. author Ingles, Sue Ann author Isaacs, Claudine author Jakubowska, Anna author James, Paul author Jenkins, Mark A. author Johansson, Mattias author Johansson, Mikael author John, Esther M. author Joshi, Amit D. author Kaneva, Radka author Karlan, Beth Y. author Kelemen, Linda E. author Kühl, Tabea author Khaw, Kay-Tee author Khusnutdinova, Elza author Kibel, Adam S. author Kiemeney, Lambertus A. author Kim, Jeri author Kjaer, Susanne K. author Knight, Julia A. author Kogevinas, Manolis author Kote-Jarai, Zsofia author Koutros, Stella author Kristensen, Vessela N. author Kupryjanczyk, Jolanta author Lacko, Martin author Lam, Stephan author Lambrechts, Diether author Landi, Maria Teresa author Lazarus, Philip author Le, Nhu D. author Lee, Eunjung author Lejbkowicz, Flavio author Lenz, Heinz-Josef author Leslie, Goska author Lessel, Davor author Lester, Jenny author Levine, Douglas A. author Li, Li author Li, Christopher I. author Lindblom, Annika author Lindor, Noralane M. author Liu, Geoffrey author Loupakis, Fotios author Lubiński, Jan author Maehle, Lovise author Maier, Christiane author Mannermaa, Arto author Marchand, Loic Le author Margolin, Sara author May, Taymaa author McGuffog, Lesley author Meindl, Alfons author Middha, Pooja author Miller, Austin author Milne, Roger L. author MacInnis, Robert J. author Modugno, Francesmary author Montagna, Marco author Moreno, Victor author Moysich, Kirsten B. author Mucci, Lorelei author Muir, Kenneth author Mulligan, Anna Marie author Nathanson, Katherine L. author Neal, David E. author Ness, Andrew R. author Neuhausen, Susan L. author Nevanlinna, Heli author Newcomb, Polly A. author Newcomb, Lisa F. author Nielsen, Finn Cilius author Nikitina-Zake, Liene author Nordestgaard, Børge G. author Nussbaum, Robert L. author Offit, Kenneth author Olah, Edith author Olama, Ali Amin Al author Olopade, Olufunmilayo I. author Olshan, Andrew F. author Olsson, Håkan author Osorio, Ana author Pandha, Hardev author Park, Jong Y. author Pashayan, Nora author Parsons, Michael T. author Pejovic, Tanja author Penney, Kathryn L. author Peters, Wilbert H M. author Phelan, Catherine M. author Phipps, Amanda I. author Plaseska-Karanfilska, Dijana author Pring, Miranda author Prokofyeva, Darya author Radice, Paolo author Stefansson, Kari author Ramus, Susan J. author Raskin, Leon author Rennert, Gad author Rennert, Hedy S. author Rensburg, Elizabeth J. van author Riggan, Marjorie J. author Risch, Harvey A. author Risch, Angela author Roobol, Monique J. author Rosenstein, Barry S. author Rossing, Mary Anne author Ruyck, Kim De author Saloustros, Emmanouil author Sandler, Dale P. author Sawyer, Elinor J. author Schabath, Matthew B. author Schleutker, Johanna author Schmidt, Marjanka K. author Setiawan, V. Wendy author Shen, Hongbing author Siegel, Erin M. author Sieh, Weiva author Singer, Christian F. author Slattery, Martha L. author Sorensen, Karina Dalsgaard author Southey, Melissa C. author Spurdle, Amanda B. author Stanford, Janet L. author Stevens, Victoria L. author Stintzing, Sebastian author Stone, Jennifer author Sundfeldt, Karin author Sutphen, Rebecca author Swerdlow, Anthony J. author Tajara, Eloiza H. author Tangen, Catherine M. author García Tardón, Adonina author Taylor, Jack A. author Teare, M. Dawn author Teixeira, Manuel R. author Terry, Mary Beth author Thibodeau, Stephen N. author Thomassen, Mads author Bjørge, Line author Tischkowitz, Marc author Toland, Amanda E. author Torres, Diana author Townsend, Paul A. author Travis, Ruth C. author Tung, Nadine author Tworoger, Shelley S. author Ulrich, Cornelia M. author Usmani, Nawaid author Vachon, Celine M. author Nieuwenhuysen, Els van author Vega, Ana author Aguado-Barrera, Miguel Elías author Wang, Qin author Webb, Penelope M. author Weinberg, Clarice R. author Weinstein, Stephanie author Weissler, Mark C. author Weitzel, Jeffrey N. author West, Catharine M. L. author White, Emily author Whittemore, Alice S. author Wichmann, H-Erich author Wiklund, Fredrik author Winqvist, Robert author Wolk, Alicja author Woll, Penella author Woods, Michael author Wu, Anna H. author Wu, Xifeng author Yannoukakos, Drakoulis author Zheng, Wei author Zienolddiny, Shanbeh author Ziogas, Argyrios author Zorn, Kristin K. author Lane, Jacqueline M. author Saxena, Richa author Thomas, Duncan author Hung, Rayjean J. author Diergaarde, Brenda author McKay, James D. author Peters, Ulrike author Hsu, Li author Garcia-Closas, Montserrat author Eeles, Rosalind A. author Chenevix-Trench, Georgia author Brennan, Paul J. author Haiman, Christopher A. author Simard, Jacques author Easton, Douglas F. author Gruber, Stephen B. author Pharoah, Paul D. P. author Price, Alkes L. author Pasaniuc, Bogdan author Amos, Christopher I. author Kraft, Peter author Lindström, Sara author 2019-01-29 Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis http://hdl.handle.net/10256/18262 Càncer -- Etiologia Cancer -- Etiology Shared heritability and functional enrichment across six solid cancers