2026-04-17T16:28:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/171752024-05-21T10:37:09Zcom_2072_452955com_2072_2054col_2072_452960col_2072_453079

00925njm 22002777a 4500 dc Coll Vidal, Mònica author Oliva, Antonio author Grassi, Simone author Brugada, Ramon author Campuzano Larrea, Oscar author 2019-04-23 Epilepsy is a common neurological disorder associated with increased morbidity and mortality. Sudden unexpected death in epilepsy, also known as SUDEP, is the main cause of death in patients with epilepsy. SUDEP has an incidence of 1.2 per 1000 person-years in adults and 0.2 per 1000 person-years in children. SUDEP accounts for 8–17% of deaths in patients with epilepsy. It is commonly associated with a history of generalized tonic-clonic seizures, and its risk may be increased by other factors such as postictal electroencephalographic suppression, prone sleeping position, altered heart rate variability, conduction abnormalities, gender, or antiepileptic medications. Recently, electrocardiograms, electroencephalograms, and imaging markers have helped clinicians stratify SUDEP risk and identify patients in need of close monitoring. However, the pathophysiology of SUDEP is likely multifactorial and still unknown. Improving the knowledge of SUDEP incidence, risk factors, and biomarkers can help design and implement effective prevention strategies This work was supported by Obra Social “La Caixa”, Fondo Investigacion Sanitaria (PI17/01690) from Instituto Salud Carlos III (ISCIII), and “Fundacio Privada Daniel Bravo Andreu”. CIBERCV is an initiative of the ISCIII, Spanish Ministry of Economy and Competitiveness. This work has been supported by Fondi Linea D1—Università Cattolica del Sacro Cuore, Italy http://hdl.handle.net/10256/17175 Mort sobtada Sudden death Epilèpsia -- Aspectes genètics Epilepsy -- Genetic aspects Update on the genetic basis of sudden unexpected death in epilepsy