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oai:recercat.cat:10256/160642024-06-18T13:36:14Zcom_2072_452955com_2072_2054col_2072_452958

Increase in Sialylation and Branching in the Mouse Serum N-glycome Correlates with Inflammation and Ovarian Tumour Progression Saldova, Radka Piccard, Helene Pérez Garay, Marta Harvey, David J. Struwe, Weston B. Galligan, Marie Berghmans, Nele Madden, Stephen F. Peracaula Miró, Rosa Opdenakker, Ghislain Rudd, Pauline M. Ovaris -- Càncer Ovaries -- Cancer Marcadors tumorals Tumor markers Ovarian cancer is the most lethal gynaecological cancer and is often diagnosed in late stage, often as the result of the unavailability of sufficiently sensitive biomarkers for early detection, tumour progression and tumour-associated inflammation. Glycosylation is the most common posttranslational modification of proteins; it is altered in cancer and therefore is a potential source of biomarkers. We investigated the quantitative and qualitative effects of anti-inflammatory (acetylsalicylic acid) and pro-inflammatory (thioglycolate and chlorite-oxidized oxyamylose) drugs on glycosylation in mouse cancer serum. A significant increase in sialylation and branching of glycans in mice treated with an inflammation-inducing compound was observed. Moreover, the increases in sialylation correlated with increased tumour sizes. Increases in sialylation and branching were consistent with increased expression of sialyltransferases and the branching enzyme MGAT5. Because the sialyltransferases are highly conserved among species, the described changes in the ovarian cancer mouse model are relevant to humans and serum N-glycome analysis for monitoring disease treatment and progression might be a useful biomarker 2013-08-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed http://hdl.handle.net/10256/16064 http://hdl.handle.net/10256/16064 eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0071159 info:eu-repo/semantics/altIdentifier/eissn/1932-6203 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Public Library of Science (PLoS) PLoS ONE, 2013, vol. 8, núm. 8, p. e71159 Articles publicats (D-B)