2026-04-13T02:28:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/140462024-06-18T12:16:58Zcom_2072_452955com_2072_2054col_2072_453069

Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma Puig Alcántara, Josep Sánchez González, Javier Blasco Solà, Gerard Daunis-i-Estadella, Pepus Federau, Christian Alberich Bayarri, Ángel Biarnés, Carles Nael, Kambiz Essig, Marco Jain, Rajan Wintermark, Max Pedraza, S. Ressonància magnètica Magnetic resonance Cervell -- Tumors Brain -- Tumors Gliomes Gliomas Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses. Results We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy. Conclusions The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastoma 2024-06-18T12:16:58Z 2024-06-18T12:16:58Z 2024-06-18T12:16:58Z 2016-07-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10256/14046 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0158887 info:eu-repo/semantics/altIdentifier/eissn/1932-6203 Attribution 4.0 Spain http://creativecommons.org/licenses/by4.0/es/ info:eu-repo/semantics/openAccess Public Library of Science (PLoS) PLoS One, 2016, vol. 11, núm. 7, p. e0158887 Articles publicats (D-IMA)