2026-04-17T01:26:56Zhttps://recercat.cat/oai/requestoai:recercat.cat:10256/140462024-06-18T12:16:58Zcom_2072_452955com_2072_2054col_2072_453069
RECERCAT
author
Puig Alcántara, Josep
author
Sánchez González, Javier
author
Blasco Solà, Gerard
author
Daunis-i-Estadella, Pepus
author
Federau, Christian
author
Alberich Bayarri, Ángel
author
Biarnés, Carles
author
Nael, Kambiz
author
Essig, Marco
author
Jain, Rajan
author
Wintermark, Max
author
Pedraza, S.
2024-06-18T12:16:58Z
2024-06-18T12:16:58Z
2016-07-07
http://hdl.handle.net/10256/14046
Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma.
Methods
Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses.
Results
We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy.
Conclusions
The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastoma
Attribution 4.0 Spain http://creativecommons.org/licenses/by4.0/es/ info:eu-repo/semantics/openAccess
Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion