2026-04-17T04:18:19Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/140242024-05-21T10:36:23Zcom_2072_452955com_2072_2054col_2072_452960col_2072_453079

00925njm 22002777a 4500 dc Carreras Badosa, Gemma author Prats Puig, Anna author Puig i Miquel, Teresa author Vázquez Ruíz, Montserrat author Bruel, Montserrat author Mendoza, Ericka author De Zegher, Francis author Ibáñez, Lourdes author López-Bermejo, Abel author Bassols Casadevall, Judit author 2016-04-19 The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). At birth, newborns and placentas were weighed. FASN expression was also able to be assessed in 80 placentas. Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p < 0.05 to p < 0.001). Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05). Our observations suggest a physiological role of placental FASN in human pregnancy. Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother’s insulin sensitivity and blood pressure http://hdl.handle.net/10256/14024 Síndrome metabòlica Metabolic syndrome Embarassades Pregnant women Hipertensió Hypertension Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters