2026-04-14T07:06:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:10256/131302024-06-18T13:51:52Zcom_2072_452955com_2072_2054col_2072_453073

A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water Valls Cantenys, Carme Scheurer, Marco Iglesias Juncà, Mònica Sacher, Frank Brauch, Heinz Jürgen Salvadó Martín, Victòria Ministerio de Ciencia e Innovación (Espanya) Ministerio de Economía y Competitividad (Espanya) Cromatografia de líquids Liquid chromatography Contaminants emergents en l'aigua Emerging contaminants in water Aigua -- Contaminació Water -- Pollution A sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammatory drugs, five iodinated contrast media, β-blockers and some of their metabolites and transformation products in water samples. Few other methods are capable of determining such a broad range of contrast media together with other analytes. We studied the parameters affecting the extraction of the target analytes, including sorbent selection and extraction conditions, their chromatographic separation (mobile phase composition and column) and detection conditions using two ionisation sources: electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI). In order to correct matrix effects, a total of 20 surrogate/internal standards were used. ESI was found to have better sensitivity than APCI. Recoveries ranging from 79 to 134 % for tap water and 66 to 144 % for surface water were obtained. Intra-day precision, calculated as relative standard deviation, was below 34 % for tap water and below 21 % for surface water, groundwater and effluent wastewater. Method quantification limits (MQL) were in the low ng L−1 range, except for the contrast agents iomeprol, amidotrizoic acid and iohexol (22, 25.5 and 17.9 ng L−1, respectively). Finally, the method was applied to the analysis of 56 real water samples as part of the validation procedure. All of the compounds were detected in at least some of the water samples analysed This study was financed by the SpanishMinistry of Science and Innovation through projects CTM2011-28765-C02-02 and CGL2013-48802-C3-2-R, and an FPI grant (Ref. BES-2009-024892) awarded to C. Valls-Cantenys info:eu-repo/date/embargoEnd/2026-01-01 info:eu-repo/date/embargoEnd/2026-01-01 2016-09-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10256/13130 http://hdl.handle.net/10256/13130 eng info:eu-repo/semantics/altIdentifier/doi/10.1007/s00216-016-9731-5 info:eu-repo/semantics/altIdentifier/issn/1618-2642 info:eu-repo/semantics/altIdentifier/eissn/1618-2650 info:eu-repo/grantAgreement/MICINN//CTM2011-28765-C02-02/ES/COMPORTAMIENTO Y ELIMINACION DE CONTAMINANTES ORGANICOS EMERGENTES EN SISTEMAS DE TRATAMIENTOS DE AGUAS. EVALUACION DE SISTEMAS TERCIARIOS./ info:eu-repo/grantAgreement/MINECO//CGL2013-48802-C3-2-R/ES/EVALUACION DE LOS EFECTOS DEL USO DE AGUAS NO CONVENCIONALES EN LA ZONA NO SATURADA Y SATURADA. ENFOQUE MULTIDISCIPLINAR/ Tots els drets reservats info:eu-repo/semantics/embargoedAccess application/pdf Springer Verlag © Analytical and Bioanalytical Chemistry, 2016, vol. 408, núm. 22, p. 6189-6200 Articles publicats (D-Q)