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Allenes, versatile unsaturated motifs in transitionmetal-catalysed [2+2+2] cycloaddition reactions Lledó Ponsati, Agustí Pla i Quintana, Anna Roglans i Ribas, Anna Ministerio de Economía y Competitividad (Espanya) Generalitat de Catalunya. Agència de Gestió d'Ajuts Universitaris i de Recerca Ciclització (Química) Ring formation (Chemistry) Reaccions d'addició Addition reactions Al·lens Allenes The development of efficient reactions that enable the construction of multiple bonds and/or stereogenic centres in a single synthetic operation is of great interest for greener and step-economical syntheses of complex organic targets. Transition-metal-catalysed [2+2+2] cycloadditions excell in this regard: no fewer than three new sigma bonds and a new ring system are formed from simple unsaturated components. Allenes constitute an important subclass among these. They are more reactive than simple alkenes and generate sp3 centres, with important stereochemical implications. In addition, further manipulation of the resulting cycloadduct through the remaining double bond is possible, increasing molecular complexity. This tutorial review highlights the value that allenes have as reagents in [2+2+2] cycloaddition and their great versatility for the development of methods to generate complex architectures We gratefully acknowledge the financial support of our own research in this area by the Spanish Ministry of Education and Science (MINECO) (Project CTQ2014-54306-P and a RyC contract to A. L.) and the DIUE of the Generalitat de Catalunya (Project 2014-SGR-931) 2016-02-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10256/12059 http://hdl.handle.net/10256/12059 eng info:eu-repo/semantics/altIdentifier/doi/10.1039/C5CS00535C info:eu-repo/semantics/altIdentifier/issn/0306-0012 info:eu-repo/semantics/altIdentifier/eissn/1460-4744 info:eu-repo/grantAgreement/MINECO//CTQ2014-54306-P/ES/ESTUDIOS TEORICO-EXPERIMENTALES DE CICLACIONES CATALIZADAS POR METALES DE TRANSICION. NUEVOS DESARROLLOS EN AROMATICIDAD, FUNCIONALES DE LA DENSIDAD Y QUIMICA SUPRAMOLECULAR/ AGAUR/2014-2016/2014 SGR-931 Reconeixement-NoComercial 3.0 Espanya http://creativecommons.org/licenses/by-nc/3.0/deed.ca info:eu-repo/semantics/openAccess application/pdf Royal Society of Chemistry (RSC) © Chemical Society Reviews, 2016, vol. 45, núm. 8, p. 2010-2023 Articles publicats (D-Q) Lledó Ponsati, Agustí Pla i Quintana, Anna Roglans i Ribas, Anna 2016 Allenes, versatile unsaturated motifs in transitionmetal-catalysed [2+2+2] cycloaddition reactions Chemical Society Reviews