2026-04-17T16:22:08Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/730342026-04-15T19:44:39Zcom_2072_6col_2072_452952

Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception Caballero, Ignacio Mbouamboua, Yvon Weise, Susanne López-Gálvez, Raquel Couralet, Marie Fleurot, Isabelle Pons, Nicolas Barrera Conde, Andrea Quílez-Playán, Nayima Keller, Matthieu Klymiuk, Nikolai Robledo, Patricia, 1958- Hummel, Thomas Barbry, Pascal Chamero, Pablo Fibrosi quística Epiteli Trastorns olfactius A reduced sense of smell is a common condition in people with cystic fibrosis (CF) that negatively affects their quality of life. While often attributed to nasal mucosa inflammation, the underlying causes of the olfactory loss remain unknown. Here, we characterized gene expression in olfactory epithelium cells from patients with CF using single-nuclei RNA sequencing and found altered expression of olfactory receptors (ORs) and genes related to progenitor cell proliferation. We confirmed these findings in newborn, inflammation-free samples of a CF animal model and further identified ultrastructural alterations in the olfactory epithelium and bulbs of these animals. We established that CFTR, the anion channel whose dysfunction causes CF, is dispensable for odor-evoked signaling in sensory neurons, yet CF animals displayed defective odor-guided behaviors consistent with the morphological and molecular alterations. Our study highlights CF's major role in modulating epithelial structure and OR expression, shedding light on the mechanisms contributing to olfactory loss in CF. 2026-04-15T19:44:39Z 2026-04-15T19:44:39Z 2026-04-14T07:21:40Z 2026-04-14T07:21:40Z 2025 2026-04-14T07:21:40Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://hdl.handle.net/10230/73034 Science advances. 2025 Feb 28;11(9):eads1568 © 2025 the Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. no claim tooriginal U.S.Government Works.distributed under a Creative commons Attribution non Commercial license 4.0 (http://creativecommons.org/licenses/by-nc/4.0). http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess American Association for the Advancement of Science (AAAS)