2026-04-17T14:59:39Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/720502025-12-05T15:18:28Zcom_2072_6col_2072_452952
2025-12-05T15:18:28Z
urn:hdl:10230/72050
Omega-3 blood levels and stroke risk: A pooled and harmonized analysis of 183 291 participants from 29 prospective studies
O'Keefe, James H.
Sala Vila, Aleix
Lázaro, Iolanda
Mozaffarian, Dariush
Atrial fibrillation
Cerebrovascular disease
Fish
Fish oil
Stroke
Background: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. Methods: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. Results: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. Conclusions: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
2025-12-05T15:18:28Z
2025-12-05T15:18:28Z
2025-11-28T13:21:12Z
2025-11-28T13:21:12Z
2024
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://hdl.handle.net/10230/72050
Stroke. 2024 Jan;55(1):50-8
© American Hearth Association http://dx.doi.org/10.1161/STROKEAHA.123.044281
info:eu-repo/semantics/openAccess
American Hearth Association