2026-04-17T07:42:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/711892025-09-16T10:13:00Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Saiz-Vivó, Marta author Mill, Jordi author Aguado, Ainhoa M. author Rochelle, Nahomy author Barredo, Anna author Albors Lucas, Carlos author Font Murillo, Mònica author Cepas-Guillen, Pedro L. author Freixa, Xavier author Barreiro-Perez, Manuel author Camara, Oscar author 2025-09-15T06:16:22Z 2025 info:eu-repo/date/embargoEnd/2026-09-12 Atrial Fibrillation affects 33.5 million people worldwide. It is associated with life-threatening consequences such as stroke, placing a heavy burden on healthcare resources. Stroke prevention is based on administering direct oral anticoagulants (DOACs) and for those contraindicated left atrial appendage occlusion (LAAO) is recommended. Still, after LAAO, a short-term period of anticoagulation is needed to avoid device-related thrombus. Predicting the minimal dose of anticoagulant administered after the intervention might reduce DOAC’s side effects. Therefore, we present a multi-therapeutic model that combines LAAO flow simulations with DOAC monitoring. Six simulations representing different clinical practice scenarios are performed: LAAO covering and uncovering the pulmonary ridge with or without 2.5 mg apixaban. Results show that applying 2.5 mg of Apixaban reduces the risk of DRT no matter the position of the occluder in the pulmonary ridge. Future steps should address the integration of more anticoagulant therapies. Despite being a proof-of-concept, we successfully developed a multi-therapeutic approach that evaluates the formation of DRT in different clinical scenarios. This study was funded by the Spanish Ministry of Science (GENERALITAAT: PID2022-143239OB-I00) and the European Union (GA 101136438- GEMINI and 101016496 Sim-CardioTest). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Agency. Neither the European Union nor the granting authority can be held responsible for them. http://hdl.handle.net/10230/71189 Left atrial appendage occlusion Haemodynamic modelling Transseptal puncture Automatic identification of optimal transseptal puncture localization and device configuration with patient-specific haemodynamic modelling in patients undergoing left atrial appendage occlusion