2026-04-18T07:45:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/702352025-04-30T20:02:55Zcom_2072_6col_2072_452952

Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis Brune-Ingebretsen, Synne Høgestøl, Einar A. de Rosbo, Nicole Kerlero Berg-Hansen, Pål Brunborg, Cathrine Blennow, Kaj Zetterberg, Henrik Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Harbo, Hanne F. Berge, Tone Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320). 2025-04-29T09:44:34Z 2025-04-29T09:44:34Z 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Brune-Ingebretsen S, Høgestøl EA, de Rosbo NK, Berg-Hansen P, Brunborg C, Blennow K, et al. Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis. J Neuroimmunol. 2023 Sep;382:578175. DOI: 10.1016/j.jneuroim.2023.578175 0165-5728 http://hdl.handle.net/10230/70235 http://dx.doi.org/10.1016/j.jneuroim.2023.578175 http://hdl.handle.net/10230/70235 eng Journal of Neuroimmunology. 2023 Sep;382:578175 info:eu-repo/grantAgreement/EC/H2020/101053962 © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Elsevier