2026-04-14T03:28:27Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/702352025-04-30T20:02:55Zcom_2072_6col_2072_452952
RECERCAT
author
Brune-Ingebretsen, Synne
author
Høgestøl, Einar A.
author
de Rosbo, Nicole Kerlero
author
Berg-Hansen, Pål
author
Brunborg, Cathrine
author
Blennow, Kaj
author
Zetterberg, Henrik
author
Paul, Friedemann
author
Uccelli, Antonio
author
Villoslada, Pablo
author
Harbo, Hanne F.
author
Berge, Tone
2025-04-30T20:02:55Z
2025-04-30T20:02:55Z
2025-04-29T09:44:34Z2025-04-29T09:44:34Z2023
http://hdl.handle.net/10230/70235
Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320).
© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion