2026-04-17T20:14:54Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/702352025-04-30T20:02:55Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Brune-Ingebretsen, Synne author Høgestøl, Einar A. author de Rosbo, Nicole Kerlero author Berg-Hansen, Pål author Brunborg, Cathrine author Blennow, Kaj author Zetterberg, Henrik author Paul, Friedemann author Uccelli, Antonio author Villoslada, Pablo author Harbo, Hanne F. author Berge, Tone author 2025-04-29T09:44:34Z 2025-04-29T09:44:34Z 2023 Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320). http://hdl.handle.net/10230/70235 Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis