2026-04-17T19:10:13Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/702352025-04-30T20:02:55Zcom_2072_6col_2072_452952
2025-04-30T20:02:55Z
urn:hdl:10230/70235
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
Brune-Ingebretsen, Synne
Høgestøl, Einar A.
de Rosbo, Nicole Kerlero
Berg-Hansen, Pål
Brunborg, Cathrine
Blennow, Kaj
Zetterberg, Henrik
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Harbo, Hanne F.
Berge, Tone
Multiple sclerosis
Serum neurofilament light chain
Immune cell subset frequencies
Biomarkers
Disease worsening
Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.
This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320).
2025-04-30T20:02:55Z
2025-04-30T20:02:55Z
2025-04-29T09:44:34Z
2025-04-29T09:44:34Z
2023
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://hdl.handle.net/10230/70235
Journal of Neuroimmunology. 2023 Sep;382:578175
info:eu-repo/grantAgreement/EC/H2020/101053962
© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Elsevier