2026-04-17T03:20:07Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/700912025-04-05T23:33:50Zcom_2072_6col_2072_452952
RECERCAT author Vilariño-García, Teresa author Polonio-González, María L. author Pérez Pérez, Antonio author Ribalta, Josep author Arrieta, Francisco author Aguilar, Manuel author Obaya, Juan C. author Gimeno-Orna, José A. author Iglesias, Pedro author Navarro, Jorge author Durán, Santiago author Pedro-Botet, Juan Carlos author Sánchez-Margalet, Víctor 2025-04-05T23:33:50Z 2025-04-05T23:33:50Z 2025-04-04T06:15:22Z2025-04-04T06:15:22Z2024 http://hdl.handle.net/10230/70091 Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in every 11 adults; among them, 90-95% of cases are type 2 diabetes mellitus. This is partly attributed to the surge in the prevalence of obesity, which has reached epidemic proportions since 2008. In these patients, cardiovascular (CV) risk stands as the primary cause of morbidity and mortality, placing a substantial burden on healthcare systems due to the potential for macrovascular and microvascular complications. In this context, leptin, an adipocyte-derived hormone, plays a fundamental role. This hormone is essential for regulating the cellular metabolism and energy balance, controlling inflammatory responses, and maintaining CV system homeostasis. Thus, leptin resistance not only contributes to weight gain but may also lead to increased cardiac inflammation, greater fibrosis, hypertension, and impairment of the cardiac metabolism. Understanding the relationship between leptin resistance and CV risk in obese individuals with type 2 DM (T2DM) could improve the management and prevention of this complication. Therefore, in this narrative review, we will discuss the evidence linking leptin with the presence, severity, and/or prognosis of obesity and T2DM regarding CV disease, aiming to shed light on the potential implications for better management and preventive strategies. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Cardiovascular risk Inflammation Leptin Obesity Type 2 diabetes mellitus Role of leptin in obesity, cardiovascular disease, and Type 2 diabetes info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion