2026-04-17T02:23:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/700912025-04-05T23:33:50Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Vilariño-García, Teresa author Polonio-González, María L. author Pérez Pérez, Antonio author Ribalta, Josep author Arrieta, Francisco author Aguilar, Manuel author Obaya, Juan C. author Gimeno-Orna, José A. author Iglesias, Pedro author Navarro, Jorge author Durán, Santiago author Pedro-Botet, Juan Carlos author Sánchez-Margalet, Víctor author 2025-04-04T06:15:22Z 2025-04-04T06:15:22Z 2024 Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in every 11 adults; among them, 90-95% of cases are type 2 diabetes mellitus. This is partly attributed to the surge in the prevalence of obesity, which has reached epidemic proportions since 2008. In these patients, cardiovascular (CV) risk stands as the primary cause of morbidity and mortality, placing a substantial burden on healthcare systems due to the potential for macrovascular and microvascular complications. In this context, leptin, an adipocyte-derived hormone, plays a fundamental role. This hormone is essential for regulating the cellular metabolism and energy balance, controlling inflammatory responses, and maintaining CV system homeostasis. Thus, leptin resistance not only contributes to weight gain but may also lead to increased cardiac inflammation, greater fibrosis, hypertension, and impairment of the cardiac metabolism. Understanding the relationship between leptin resistance and CV risk in obese individuals with type 2 DM (T2DM) could improve the management and prevention of this complication. Therefore, in this narrative review, we will discuss the evidence linking leptin with the presence, severity, and/or prognosis of obesity and T2DM regarding CV disease, aiming to shed light on the potential implications for better management and preventive strategies. http://hdl.handle.net/10230/70091 Cardiovascular risk Inflammation Leptin Obesity Type 2 diabetes mellitus Role of leptin in obesity, cardiovascular disease, and Type 2 diabetes