2026-04-17T15:06:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/696012025-12-22T20:20:33Zcom_2072_6col_2072_452954

00925njm 22002777a 4500 dc Cases Gendra, Jan author 2025-02-13T11:53:45Z 2025-02-13T11:53:45Z 2024 Treball de Fi de Grau en Enginyeria Biomèdica. Curs 2023-2024 Tutors: Ralph G. Andrzejak, Giulio Ruffini, Francesca Castaldo i Edmundo Lopez-Sola Background – Psychedelics hold great potential to treat various mental disorders, yet their neurobiological mechanisms remain unclear. Recent mechanistic models have provided valuable insights into the impact of serotonergic psychedelics on brain dynamics. However, these models focus mainly on macroscale brain activity and provide limited information on the psychedelics’ mechanisms at the neural population level. Methods – We provide a novel mechanistic explanation of the well-studied power spectrum alterations in spontaneous cortical activity observed under serotonergic psychedelics. We combine a physiologically grounded whole-brain model optimised with multimodal neuroimaging of healthy human participants with neurotransmitter data from positron emission tomography (PET) of the serotonin 2A receptor (5-HT2AR) density map. Building upon the recent laminar neural mass modelling (LaNMM) framework (Sanchez-Todo et al., 2023), the whole-brain model simulates multiband activity and electrophysiological measurements of the cortical columns, where the 5-HT2AR density controls the average synaptic gain of excitatory connections to layer 5 pyramidal neural populations, known to be rich in 5-HT2ARs. Results – Our findings suggest that the decrease in spontaneous cortical oscillatory power in the alpha band and increase in the gamma band are mainly influenced by the 5-HT2AR-mediated excitation of deep-layer pyramidal cells. These findings explain the functional effects of 5-HT2AR activation with psychedelics and allow us to propose a novel whole-brain biologically-informed explanation for this phenomenon detailed at the mesoscale and based on NMMs. Perspectives – This model provides valuable insight into the mechanistic underpinnings of psychedelic action in the brain and could be employed to investigate the neuromodulatory potential of psychedelics in re-establishing healthy brain dynamics in mental disorders. Treball de fi de grau – Curs 2023-2024 Neuropsychiatry Psychedelics Serotonin PET Whole-brain model NMM Neuromodulation A novel biophysical whole-brain model explains power spectrum alterations of serotonergic psychedelics