2026-04-13T07:36:51Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/609902025-12-12T02:02:47Zcom_2072_6col_2072_452952
RECERCAT author Alcolea, Jose A. author Donat-Vargas, Carolina author Chatziioannou, Anastasia Chrysovalantou author Keski-Rahkonen, Pekka author Robinot, Nivonirina author Molina, Antonio J. author Amiano, Pilar author Gómez-Acebo, Inés author Castaño Vinyals, Gemma author Maitre, Léa author Chadeau-Hyam, Marc author Dagnino, Sonia author Cheng, Sibo Lucas author Scalbert, Augustin author Vineis, Paolo author Kogevinas, Manolis author Villanueva Belmonte, Cristina 2024-09-03T12:40:55Z2023 We investigated the metabolomic profile associated with exposure to trihalomethanes (THMs) and nitrate in drinking water and with colorectal cancer risk in 296 cases and 295 controls from the Multi Case-Control Spain project. Untargeted metabolomic analysis was conducted in blood samples using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. A variety of univariate and multivariate association analyses were conducted after data quality control, normalization, and imputation. Linear regression and partial least-squares analyses were conducted for chloroform, brominated THMs, total THMs, and nitrate among controls and for case-control status, together with a N-integration model discriminating colorectal cancer cases from controls through interrogation of correlations between the exposure variables and the metabolomic features. Results revealed a total of 568 metabolomic features associated with at least one water contaminant or colorectal cancer. Annotated metabolites and pathway analysis suggest a number of pathways as potentially involved in the link between exposure to these water contaminants and colorectal cancer, including nicotinamide, cytochrome P-450, and tyrosine metabolism. These findings provide insights into the underlying biological mechanisms and potential biomarkers associated with water contaminant exposure and colorectal cancer risk. Further research in this area is needed to better understand the causal relationship and the public health implications. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental science & technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.est.3c05814. info:eu-repo/semantics/openAccess -omics Blood Colorectal cancer Disinfection byproducts Drinking water Environment Epidemiology Exposome Exposure Metabolomics Nitrate Trihalomethanes Untargeted Metabolomic signatures of exposure to nitrate and trihalomethanes in drinking water and colorectal cancer risk in a Spanish Multicentric Study (MCC-Spain) info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion