2026-04-14T09:04:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/591072025-12-12T02:07:46Zcom_2072_6col_2072_452952

RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12 Salgado, Heladia Gelpí, Josep Lluís Collado Vides, Pedro Julio Biologia molecular Regulació genètica RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experience. The integration of graphical tools provides clear visual representations of genetic regulation data, facilitating data interpretation and knowledge integration. RegulonDB version 12.0 can be accessed at https://regulondb.ccg.unam.mx. 2024-02-14T10:58:07Z 2024-02-14T10:58:07Z 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salgado H, Gama-Castro S, Lara P, Mejia-Almonte C, Alarcón-Carranza G, López-Almazo AG et al. RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12. Nucleic Acids Res. 2024 Jan 5;52(D1):D255-64. DOI: 10.1093/nar/gkad1072 0305-1048 http://hdl.handle.net/10230/59107 http://dx.doi.org/10.1093/nar/gkad1072 eng Nucleic Acids Res. 2024 Jan 5;52(D1):D255-64 © The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Oxford University Press