2026-04-14T09:05:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/589522025-12-22T13:47:24Zcom_2072_6col_2072_452952

What is a bladder cancer molecular subtype? – Counterpoint Radvanyi, François Real, Francisco X. McConkey, David Bladder cancer Molecular subtypes Tumor classification Genomics Tumor microenvironment Prediction of outcome In an accompanying paper, Mattias Hoglund discusses on what is a bladder cancer molecular subtype. He emphasizes the need to consider the aim of tumor classification, which is obviously critical to the approach. He also focuses on considering primarily the identity features of the neoplastic cells. Here, we provide a counterpoint. While largely agreeing with his views, we underline that other parameters that may vary in a spatial or temporal scale, and the tumor microenvironment, can also provide relevant information to render tumor classifications clinically useful. Furthermore, tumor heterogeneity and evolution during the disease course - natural or under therapeutic pressure - should be considered. 2024-02-05T14:01:21Z 2024-02-05T14:01:21Z 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Radvanyi F, Real FX, McConkey D. What is a bladder cancer molecular subtype? - Counterpoint. Bladder Cancer. 2023;9(4):299-304. DOI: 10.3233/BLC-230059 2352-3727 http://hdl.handle.net/10230/58952 http://dx.doi.org/10.3233/BLC-230059 eng Bladder Cancer. 2023;9(4):299-304 © 2023 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf IOS Press