2026-04-18T00:26:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/589522025-12-22T13:47:24Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Radvanyi, François author Real, Francisco X. author McConkey, David author 2024-02-05T14:01:21Z 2024-02-05T14:01:21Z 2023 In an accompanying paper, Mattias Hoglund discusses on what is a bladder cancer molecular subtype. He emphasizes the need to consider the aim of tumor classification, which is obviously critical to the approach. He also focuses on considering primarily the identity features of the neoplastic cells. Here, we provide a counterpoint. While largely agreeing with his views, we underline that other parameters that may vary in a spatial or temporal scale, and the tumor microenvironment, can also provide relevant information to render tumor classifications clinically useful. Furthermore, tumor heterogeneity and evolution during the disease course - natural or under therapeutic pressure - should be considered. Bladder cancer Molecular subtypes Tumor classification Genomics Tumor microenvironment Prediction of outcome What is a bladder cancer molecular subtype? – Counterpoint